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KMID : 1123920020160010089
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.89 ~ p.94
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Effect of Gamisamul-tang on hyperlipidemia in Ovariectomized Rats
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Jeong Young-Sub
Lee Yong-Tae
Kang Kyung-Hwa
Kim Gyeong-Cheol
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Abstract
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Effect of Gamisamul-tang(GS) on body weight, uterine weight, splenial weight, serum and estrogen receptor-α (ER-α) in kidney were investigated in ovariectomized(OVX) rats. Female Sprague -Dawley rats with a body weight of 220 g were undergone ovariectomy or sham operation. The ovariectomy caused significant decrease in serum levels of HDL-cholesterol and in uterine weight compared to those of sham-operated animals. while caused significant increase in serum levels of total cholesterol, LDL-cholesterol, triglyceride, body weight and in splenial weight. In contrast, administration of OVX rats with the GS significantly elevated serum levels of HDL-cholesterol and uterine weight, but significantly depressed serum levels of total cholesterol, LDL-cholesterol, triglyceride, body weight and in splenial weight. ER-α localized in the kidney vessel endothelial cells and its expression was increased by ovariectomy and decreased by administration of OVX rats with the GS. Our results suggest that a possible protective effect of as against hyperlipidemia in postmenopausal cardiovascular disease and as increase the estrogen-estrogen receptor romp/ex in the kidney vessel endothelial cells.
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KEYWORD
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Gamisamul-tang(加味四物湯), ovariectomized(OVX) rats, ER-α, estrogen-estrogen receptor complex
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